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Sleepem contains St. John's Wort, a well-documented inducer of cytochrome P450 enzymes. This can reduce the effectiveness of a wide range of prescription drugs, including antidepressants (SSRIs, SNRIs, MAOIs — with potential serotonin syndrome risk), hormonal contraceptives, anticoagulants including warfarin, cyclosporine, statins, HIV antiretrovirals, certain cancer medications, and heart medications including digoxin. This is not an exhaustive list. If you take any prescription medication, disclose this ingredient to your doctor or pharmacist before use.
At 10mg, Sleepem's melatonin dose is higher than many researchers consider necessary; next-day grogginess is possible. 5-HTP can interact with medications that affect serotonin levels, including SSRIs, SNRIs, MAOIs and certain migraine medications.
Not for use by those under 18, pregnant or nursing individuals, or anyone with a known medical condition, particularly those taking medications for anxiety, depression or a sleep disorder, without first consulting a physician.
14 of the formula's 17 ingredients sit inside a 905mg proprietary blend with no individual amounts disclosed. We cannot confirm the strength of any single blend ingredient in a daily serving.
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