Sleepem Ingredients
Sleepem names 17 ingredients: 3 individually dosed and 14 inside a 905mg proprietary blend.
St. John's Wort and 5-HTP both carry real medication-interaction considerations, detailed below.
Individually dosed vs. the proprietary blend
Sleepem discloses three ingredients individually — Vitamin B6 (1.8mg), Magnesium Citrate (13mg) and Melatonin (10mg) — and names 14 more inside a 905mg proprietary blend, listed in order on the label but without individual amounts. This is a real limitation for comparing the blend's components against published clinical research dosages.
All 17 ingredients, one by one
Vitamin B6 (Pyridoxine HCl) — 1.8mg (106% DV)
Supports the enzymatic conversion of amino acids into serotonin and melatonin, a co-factor role that complements the tryptophan and 5-HTP content.
Magnesium (as Magnesium Citrate) — 13mg (3% DV)
A modest supporting dose — sleep-focused magnesium research typically uses 200–400mg, so this is not the formula's primary active.
Melatonin — 10mg
The most-studied sleep-support ingredient. This dose sits at the higher end of commercially available products — see our dedicated dosing note.
L-Tryptophan — Part of 905mg blend
An essential amino acid and direct precursor to serotonin, which the body converts to melatonin.
Lycium (goji berry) — Part of 905mg blend
A traditional berry included in the formula's broader wellness framing.
Chamomile — Part of 905mg blend
Among the most-studied relaxant botanicals, with research noting its apigenin content and interaction with GABA receptors.
Lemon Balm — Part of 905mg blend
A traditional botanical with anxiolytic and calming associations in ethnobotanical literature.
Passionflower — Part of 905mg blend
A 2011 double-blind trial in Phytotherapy Research found improved sleep quality scores compared to placebo.
L-Taurine — Part of 905mg blend
An amino acid included in the formula's calming architecture.
Hops — Part of 905mg blend
A traditional botanical with sedative associations in pharmacological literature.
St. John's Wort — Part of 905mg blend
A traditional sleep-supportive botanical that carries a significant, well-documented drug-interaction profile — see our safety note below.
GABA — Part of 905mg blend
The body's primary inhibitory neurotransmitter, described as a natural brake for an overactive brain.
Skullcap — Part of 905mg blend
A traditional botanical with anxiolytic and sedative associations, though large clinical trials remain limited.
L-Theanine — Part of 905mg blend
A calming amino acid found naturally in tea leaves, granted GRAS status by the FDA, associated with alpha brain wave activity.
Ashwagandha — Part of 905mg blend
An adaptogen with a substantial research base on stress, cortisol and sleep quality.
Inositol — Part of 905mg blend
Included in the formula's calming architecture alongside the other blend ingredients.
5-HTP — Part of 905mg blend
Converts more directly to serotonin than L-tryptophan; carries its own medication-interaction caution — see our safety note below.
Two ingredients that need a real conversation with your doctor
St. John's Wort is a well-documented inducer of cytochrome P450 enzymes, which can reduce the effectiveness of many prescription drugs — antidepressants, hormonal contraceptives, blood thinners including warfarin, cyclosporine, statins, HIV antiretrovirals, certain cancer medications, and heart medications including digoxin. Disclose this ingredient to your doctor or pharmacist before starting, regardless of how minor your prescription may seem.
5-HTP can interact with medications that affect serotonin levels — SSRIs, SNRIs, MAOIs and certain migraine medications — carrying a theoretical serotonin syndrome risk. Read how the formula is meant to work next.
